Clonal, in vivo behavior of the totipotent hematopoietic stem cell.

摘要: Classical and more recent studies have provided a description of the in vivo behavior totipotent hematopoietic stem cell its clonal progeny. These reconstitution experiments, employing clonotypic markers shown that single or few engrafted lymphoid-myeloid cells are both necessary sufficient for long-term, stable hematopoiesis reconstituted mouse. This underscores remarkable developmental capacity individual clones. Furthermore, long-term retransplantation an indication self-renewal ability. Taken together, analyses also shed light on dynamic clones entire system. A model is presented where proliferative function time. In this commitment versus decisions may be governed by stochastic mechanisms. However, actual contribution to particular mature populations lineage specific demands as they change over post-engraftment