Cellular Basis of Morphogenetic Change: Looking Back after 30 Years of Progress on Developmental Signaling Pathways

摘要: The 1981 session on the Cellular Basis of Morphogenetic Change included discussions pattern formation by positional information and cellular interpretation, polyclonal compartments as developmental units selector gene expression, morphogenetic activities cells, conserved cell types, pathways revealed newly collected Drosophila mutants. All this was contributory to preparatory for great advances next decades in understanding terms cell-cell signaling transcriptional regulation, evolution development. present article is a summary some these advances, taking Bmp Wnt vertebrate embryos, which mediate large scale patterning dorsoventral anteroposterior axes embryo. covers different transduction components transcription factors activated within two when signals are received, complex yet robust adaptable means cells generate graded distributions over specific groups. Key at gastrula-neurula stages Spemann’s organizer, center early embryo that produces antagonists. themselves date back earliest metazoa, their use embryonic dates least bilaterian common ancestor. development has involved changes times places repeated usage pathways, genes targeted them (changing competence), location signal distribution.