Significant correlation of peptidyl-prolyl isomerase overexpression in merkel cell carcinoma with overall survival of patients

摘要: Background. An overexpression of PIN1, the peptidyl-prolyl cis-trans isomerase, might cause cell cycle arrest and growth inhibition by binding to p53 protein, a process leading stabilization. The rationale this retro- spective analysis was evaluate expression pattern PIN1 in Merkel carcinomas (MCCs) its suitability as prognostic factor. Methods. Samples 27 MCCs were immunhistochemically stained for correlated with overall disease-free survival patients. Results. All samples expressed PIN1. We showed signifi- cantly better patients an than weak (p ¼ .031), but not significant .821). 5-year rate 14.4% 50.9% Conclusions. seems be factor MCC. V C 2010 Wiley Periodicals, Inc. Head Neck 33: 1294-1300, 2011