Free Energy Cost of Reducing Noise while Maintaining a High Sensitivity

作者: Pablo Sartori , Yuhai Tu

DOI: 10.1103/PHYSREVLETT.115.118102

关键词:

摘要: Living systems need to be highly responsive, and also keep fluctuations low. These goals are incompatible in equilibrium due the fluctuation dissipation theorem (FDT). Here, we show that biological sensory systems, driven far from by free energy consumption, can reduce their intrinsic while maintaining high responsiveness. By developing a continuum theory of E. coli chemotaxis pathway, demonstrate adaptation understood as nonequilibrium phase transition controlled dissipation, it is characterized breaking FDT. We maximum response at short time enhanced dissipation. At same time, low frequency error decrease with algebraically exponentially, respectively.

参考文章(30)
Yuansheng Cao, Hongli Wang, Qi Ouyang, Yuhai Tu, The free-energy cost of accurate biochemical oscillations Nature Physics. ,vol. 11, pp. 772- 778 ,(2015) , 10.1038/NPHYS3412
W. Buijsman, M. Sheinman, Efficient fold-change detection based on protein-protein interactions. Physical Review E. ,vol. 89, pp. 022712- 022712 ,(2014) , 10.1103/PHYSREVE.89.022712
Ganhui Lan, Pablo Sartori, Silke Neumann, Victor Sourjik, Yuhai Tu, The energy–speed–accuracy trade-off in sensory adaptation Nature Physics. ,vol. 8, pp. 422- 428 ,(2012) , 10.1038/NPHYS2276
J. E. Niven, S. B. Laughlin, Energy limitation as a selective pressure on the evolution of sensory systems The Journal of Experimental Biology. ,vol. 211, pp. 1792- 1804 ,(2008) , 10.1242/JEB.017574
Christopher C. Govern, Pieter Rein ten Wolde, Energy dissipation and noise correlations in biochemical sensing. Physical Review Letters. ,vol. 113, pp. 258102- ,(2014) , 10.1103/PHYSREVLETT.113.258102
Y. Tu, T. S. Shimizu, H. C. Berg, Modeling the chemotactic response of Escherichia coli to time-varying stimuli Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 14855- 14860 ,(2008) , 10.1073/PNAS.0807569105
J. Prost, J.-F. Joanny, J. M. R. Parrondo, Generalized fluctuation-dissipation theorem for steady-state systems. Physical Review Letters. ,vol. 103, pp. 090601- ,(2009) , 10.1103/PHYSREVLETT.103.090601
Leticia F. Cugliandolo, Jorge Kurchan, Luca Peliti, ENERGY FLOW, PARTIAL EQUILIBRATION, AND EFFECTIVE TEMPERATURES IN SYSTEMS WITH SLOW DYNAMICS Physical Review E. ,vol. 55, pp. 3898- 3914 ,(1997) , 10.1103/PHYSREVE.55.3898