S-Triazines: As Alternative Drugs for the Treatments of Typhoid

摘要: substituted-2-thio-(1H)-4-((2-imino-4-thiobiureto-5-yl) guanyl)-6-substitutedamino-1,2-dihydro-s-triazines (3a(i) to 3f(iv)) have been obtained by the isomerisation of 2-substitutedamino-4-(2-imino-4-thiobiureto-5-yl-carbamidino)-6- substitutedimino-1,3,5-thiadiazines (2a(i) 2f(iv)) in presence ethanolic sodium bicarbonate solution, which basification their hydrochlorides (1a(i) 1f(iv)) are synthesized interaction 1-formamidino- 3-thioamido-N-substitutedformamidinothiocarbamides and N-aryl/alkylisocyanodichlorides. The latter were prepared initially condensation N-aryl/alkylisothiocyanate 1,3-Diformamidinothiocarbamide. structure all these compounds was established on basis elemental analysis IR NMR spectral data. All screened for antimicrobial activity against both gram-positive gram-negative human pathogens.