Small-molecule quadruplex-targeted drug discovery

摘要: Repeated guanine tracts in human and other genomes can form higher-order four stranded structures, termed quadruplexes. In the genome they have particular prevalence telomeric promoter regions also 5'-UTRs introns. These if unresolved stabilised by small molecules, impediments to transcription translation, thus be considered as a of gene targeting. This Digest surveys major types quadruplex-binding molecules that been designed studied date directs attention directions where future development more drug-like compounds is likely most productive.