Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures
作者： Aurélien Laguerre , Yi Chang , Marc Pirrotta , Nicolas Desbois , Claude P. Gros
DOI: 10.1039/C5OB00692A
关键词:
摘要: Scientists are currently truly committed to enhance the specificity of chemotherapeutics that target DNA. To this end, sequence-specific drugs have progressively given way structure-specific therapeutics. However, while numerous strategies been implemented design high-affinity candidates, devoted high-selectivity ligands still rare. Here we report on such an approach via study amphiphilic compound, TEGPy, self-assembles at a liquid/solid interface provide nanosized objects stable in water. The resulting aggregates, identified through atomic force microscopy measurements, were found disassemble upon interaction with DNA manner (quadruplex- versus duplex-DNA). Our results fertile ground for devising new aiming concomitantly enhancing structural and water-solubility aggregation-prone ligands.
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