CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls
作者： Elisanne A.L.M. Biemans , Nanda M. Verhoeven-Duif , Johan Gerrits , Jurgen A.H.R. Claassen , H. Bea Kuiperij
DOI: 10.1016/J.NEUROBIOLAGING.2016.03.017
关键词:
摘要: Cerebrospinal fluid (CSF) levels of d-serine were recently reported as a potential new biomarker for Alzheimer's disease (AD), showing perfect distinction between AD patients and healthy controls. In this study, we aimed to confirm these results extend previous findings dementia with Lewy bodies frontotemporal dementia. d-Serine in CSF 29 patients, 8 14 28 nondemented controls measured using ultra-high-performance liquid chromatography-tandem mass spectrometry. contrast findings, our study only slightly increased compared did not differ from other dementias was also correlated mini-mental state examination-scores. Owing the large overlap levels, conclude that is neither suitable nor cognitive decline.
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