d-serine levels in Alzheimer's disease: implications for novel biomarker development.

摘要: Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective methods diagnosis. Altered levels the NMDA receptor co-agonist, d-serine, have been associated with neurological disorders, including schizophrenia and epilepsy. However, whether d-serine are deregulated AD remains elusive. Here, we first measured D-serine post-mortem hippocampal cortical samples from nondemented subjects (n=8) patients (n=14). We next determined experimental models AD, wild-type rats mice that received intracerebroventricular injections amyloid-β oligomers, APP/PS1 transgenic mice. Finally, assessed cerebrospinal fluid (CSF) 21 diagnosis probable as compared normal pressure hydrocephalus (n=9), major depression (n=9) healthy controls (n=10), results were contrasted CSF amyloid-β/tau biomarkers. higher hippocampus parietal cortex than control subjects. Levels both serine racemase, enzyme responsible for production, elevated AD. Significantly, non-cognitively impaired subject groups. Combining to amyloid/tau index remarkably increased sensitivity specificity our cohort. Our show brain discriminated between cohort might constitute novel candidate biomarker early