Tau in Late-Life Depression: A Systematic Review and Meta-Analysis
作者： Eric E. Brown , Yusuke Iwata , Jun Ku Chung , Philip Gerretsen , Ariel Graff-Guerrero
DOI: 10.3233/JAD-160401
关键词: Major depressive disorder 、 Neuroscience 、 Oncology 、 Disease 、 Late life depression 、 Depression (differential diagnoses) 、 Cerebrospinal fluid 、 Psychology 、 Meta-analysis 、 Internal medicine 、 Clinicopathological correlation 、 Positron emission tomography
摘要: A lifetime history of major depressive disorder (MDD) increases the risk developing Alzheimer's disease, which neurofibrillary tangles due to abnormal tau proteins are a hallmark. We systematically reviewed literature on in MDD and identified 49 relevant articles spanning number modalities, including cerebrospinal fluid (CSF) analysis, positron emission tomography, clinicopathological correlation. compared CSF total phosphorylated controls using meta-analytic approach. found no difference or MDD. also comparison subgroup excluding studies with significant age differences. Positron tomography lacked specificity. Clinicopathological failed associate The available data is limited. involvement subset cannot be ruled out requires prospective exploration.
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