Neprilysin-like activity correlates with CSF-Tau and phospho-tau in patients with Alzheimer's disease.
作者： Katrine Christa Nordskov Sorensen , Anja Hviid Simonsen , Ulla Bachmann Holmetoft , Steen Gregers Hasselbalch , Niels H.H. Heegaard
DOI: 10.3233/JAD-122410
关键词:
摘要: A relation between amyloid-β peptide (Aβ) accumulation and neprilysin (NEP), an Aβ degrading enzyme, has been proposed but studies of NEP the levels pathological hallmarks Alzheimer's disease (AD), tau, in cerebrospinal fluid (CSF) are scarce. In this study, we measured level enzyme activity serum CSF, using a sandwich enzyme-linked immunosorbent assay fluorescence resonance energy transfer assay, respectively, patients with AD, frontotemporal dementia (FTD), Creutzfeldt-Jakob (CJD), depression. Results were correlated CSF AD biomarkers Aβ42, hyperphosphorylated tau (p-tau), total (t-tau). serum, found no differences NEP-like or concentration groups there correlations biomarkers. influence age gender on was seen. However, lower specific higher FTD compared to AD. Aβ42 did not correlate CJD, depression groups, significantly group. depression, p-tau, and, group, it also t-tau levels. Our results suggest that p-tau is characteristic trait The correlation unexpected warrants further investigation.
sci-hub.se 参考文章(41)
Suqing Wang, Rui Wang, Lang Chen, David A. Bennett, Dennis W. Dickson, Deng-Shun Wang, Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer’s brain Journal of Neurochemistry. ,vol. 115, pp. 47- 57 ,(2010) , 10.1111/J.1471-4159.2010.06899.X
J. Scott Miners, Zoë Van Helmond, Patrick G. Kehoe, Seth Love, Changes with Age in the Activities of β‐Secretase and the Aβ‐Degrading Enzymes Neprilysin, Insulin‐Degrading Enzyme and Angiotensin‐Converting Enzyme Brain Pathology. ,vol. 20, pp. 794- 802 ,(2010) , 10.1111/J.1750-3639.2010.00375.X
Walter Maetzler, Velichka Stoycheva, Benjamin Schmid, Claudia Schulte, Ann-Kathrin Hauser, Kathrin Brockmann, Arthur Melms, Thomas Gasser, Daniela Berg, Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body disease. Journal of Alzheimer's Disease. ,vol. 22, pp. 933- 938 ,(2010) , 10.3233/JAD-2010-101197
Maria Z Kounnas, Anne M Danks, Soan Cheng, Curtis Tyree, Elizabeth Ackerman, Xulun Zhang, Kwangwook Ahn, Phuong Nguyen, Dan Comer, Long Mao, Chengzhi Yu, David Pleynet, Paul J Digregorio, Gonul Velicelebi, Kenneth A Stauderman, William T Comer, William C Mobley, Yue-Ming Li, Sangram S Sisodia, Rudolph E Tanzi, Steven L Wagner, None, Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease Neuron. ,vol. 67, pp. 769- 780 ,(2010) , 10.1016/J.NEURON.2010.08.018
Nikolai D Belyaev, Natalia N Nalivaeva, Natalia Z Makova, Anthony J Turner, Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Reports. ,vol. 10, pp. 94- 100 ,(2009) , 10.1038/EMBOR.2008.222
R. B. DeMattos, K. R. Bales, D. J. Cummins, J.-C. Dodart, S. M. Paul, D. M. Holtzman, Peripheral anti-A antibody alters CNS and plasma A clearance and decreases brain A burden in a mouse model of Alzheimer's disease Proceedings of the National Academy of Sciences. ,vol. 98, pp. 8850- 8855 ,(2001) , 10.1073/PNAS.151261398
Justyna Maria Czarna Bahl, Niels H.H. Heegaard, Gerhard Falkenhorst, Henning Laursen, Hans Høgenhaven, Kåre Mølbak, Cathrine Jespersgaard, Lotte Hougs, Gunhild Waldemar, Peter Johannsen, Michael Christiansen, The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease. Neurobiology of Aging. ,vol. 30, pp. 1834- 1841 ,(2009) , 10.1016/J.NEUROBIOLAGING.2008.01.013
Dieter Edbauer, Michael Willem, Sven Lammich, Harald Steiner, Christian Haass, Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD) Journal of Biological Chemistry. ,vol. 277, pp. 13389- 13393 ,(2002) , 10.1074/JBC.M111571200
Malcolm A Leissring, Wesley Farris, Alice Y Chang, Dominic M Walsh, Xining Wu, Xiaoyan Sun, Matthew P Frosch, Dennis J Selkoe, None, Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death Neuron. ,vol. 40, pp. 1087- 1093 ,(2003) , 10.1016/S0896-6273(03)00787-6
Raphael Poirier, David P. Wolfer, Hans Welzl, Jay Tracy, Michael J. Galsworthy, Roger M. Nitsch, M. Hasan Mohajeri, Neuronal neprilysin overexpression is associated with attenuation of Aβ-related spatial memory deficit Neurobiology of Disease. ,vol. 24, pp. 475- 483 ,(2006) , 10.1016/J.NBD.2006.08.003