Methods for modulating nuclear receptor coactivator binding
作者： Peter J. Kushner , Weijun Feng , Brian L. West , Keith R. Yamamoto , Robert J. Fletterick
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摘要: The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor coactivator binding. includes a method identifying residues comprising binding site of interest. Also included is agonists and/or antagonists that bind Agonists receptors also are provided. exemplified by identification manipulation the thyroid (TR), this sites. can be applied other including RAR, RXR, PPAR, VDR, ER, GR, PR, MR, AR.
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