Status der koronaren Stententwicklung

作者: T. Pilgrim , S. Windecker

DOI: 10.1007/S12181-013-0537-9

关键词:

摘要: Medikamentenbeschichtete Stents der ersten Generation haben das Risiko erneuter Revaskularisationseingriffe im Vergleich zu unbeschichteten deutlich vermindert, waren aufgrund einer anhaltenden entzundlichen Reaktion aber mit einem erhohten fur Auftreten sehr spater Stentthrombosen verbunden. bestehen in Regel aus Stentgerust und antiproliferativen Substanz, die Polymermatrix freigesetzt wird. Durch Entwicklung biokompatibler biodegradierbarer Polymere wurde medikamentenbeschichteten neueren eine Reduktion des Risikos erzielt bei gleichbleibender bzw. verbesserter Effektivitat hinsichtlich Restenoseneigung. Polymerfreie medikamentenbeschichtete vollstandig biodegradierbare Stentgeruste zeigen vielversprechende Resultate kleineren Studien sind Gegenstand aktueller Untersuchungen.

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