Viruses and cancer: Herpesviruses and tumors in the head and neck: A review

摘要: P ossible associations between viruses and neoplasms have long been discussed, there is certainly conclusive evidence linking various RNA viruses’ DNA viruses2 with tumors in animals, including subhuman primates. In man, are also strong a few neoplasms.3 For example, substantial hepatitis B virus hepatoma.4 Other that known to be oncogenic include adenoviruses,5s6 papovaviruses,7 herpesviruses.2, 8 A number of herpesviruses-enveloped twenty-sided capsid (icosahedron) the characteristic latency-infect animals.g The first association herpesvirus tumor was implication renal adenocarcinoma frog.‘O Of four herpesviruses infect implicating Epstein-Barr (EBV), cytomegalovirus (CMV), herpes simplex (HSV) development some neoplasms, but little an effect varicella-zoster virus.” It interest EBV, CMV, HSV implicated may involve head neck.12 Therefore, oncogenesis discussed here. KochY3 postulates used for evaluating etiologic relationship infectious agent specific disease not strictly applicable possibility viral oncogenesis, since problems relation latency carcinogenesis, reactivation latent rather than primary infection responsible, low prevalence spite almost ubiquitous distribution most viruses. Koch’s postulates, therefore, viewed terms more oncogenesis.14