Enantioselektive Synthese von β-Aminosulfonen über azaanaloge Michael-Addition an Alkenylsulfone
作者： Dieter Enders , Stephan F. Müller , Gerhard Raabe
DOI: 10.1002/(SICI)1521-3757(19990115)111:1/2<212::AID-ANGE212>3.0.CO;2-E
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摘要: Ob SAMP oder RAMBO deren Enantiomere RAMP bzw. SAMBO als chirale Ammoniakaquivalente verwendet werden: Die asymmetrische Synthese von N-geschutzten β-Aminosulfonen 4 gelingt stets mit sehr hohen Enantiomerenuberschussen durch Addition eines Stickstoff-Nucleophils ((S)-1 (R,R,R)-2) an (E)-Alkenylsulfone 3 und anschliesende reduktive N-N-Spaltung zur Entfernung des chiralen Auxiliars.
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