Genetic and Environmental Factors Are Associated with Serum 25-Hydroxyvitamin D Concentrations in Older African Americans

摘要: Background: Low circulating 25-hydroxyvitamin D [25(OH)D] is prevalent in African Americans, but predictors of vitamin status are understudied compared to Caucasian populations. Objective: We investigated whether certain environmental and genetic factors 25(OH)D 989 elderly Americans participating the Health, Aging, Body Composition (Health ABC) Study. Methods: Regression analysis estimated cross-sectional association nongenetic (environmental) with 25(OH)D. Single nucleotide polymorphisms (SNPs) associated genome-wide studies (GWASs) were analyzed for serum 25(OH)D, including analyses all imputed SNPs identified genomic regions. Genome-wide complex trait (GCTA) evaluated (genome-wide) genotyped Health ABC Study replication Multi-Ethnic Atherosclerosis (MESA) cohort. Results: Gender, study site, season blood draw, body mass index, dietary supplement use, dairy cereal consumption, Healthy Eating Index score, walking >180 min/wk (P < 0.05), jointly explaining 25% variation Multivitamin use was strongest predictor users had a 6.3-mg/L higher concentration nonusers. Previous GWAS-identified gene regions not replicated nonsynonymous rs7041 SNP group-specific component (vitamin binding protein) close significance thresholds = 0.08), there evidence an interaction between this multivitamin supplements relation (P= 0.04). Twenty-three percent (95% CI: 0%, 52%) explained by total pooled GCTA 2087 MESA African-American participants, population substructure effects could be separated from other influences. Conclusions: Modifiable lifestyle Americans. confirms that proportion variability attributable variation, phenotype prior GWASs European J Nutr doi: 10.3945/jn.114.202093.