Restriction of neuroblastoma to the prostate gland in transgenic mice.

摘要: Abstract Male transgenic mice that carry a construct containing 5'-flanking sequences of the gp91-phox gene linked to early region simian virus 40 (SV40) genome reproducibly develop tumors arising from prostate gland. As is expressed exclusively in terminally differentiating hematopoietic cells myelomonocytic lineage, induction gland was unexpected. These lesions appear be due novel transcription signal generated during construction transgene. Surprisingly, histopathological and biochemical properties tumor are diagnostic neuroblastoma rather than adenocarcinoma Tumors produce SV40 T antigen isoforms neural cell adhesion molecule characteristic neuronal cells, they occur testosterone-independent manner. Microscopic examination glands young reveals presence small outside epithelium, which consistent with diagnosis further distinguishes this prostatic adenocarcinoma. Prostate all male animals susceptible lines carrying promoter/SV40 early-region However, variability time at gross expressing prior tumorigenesis suggest somatic events addition T-antigen production required for development malignancy. The extraordinary restriction site these indicates novel, tissue-specific neuroectodermal origin. provide model system study malignancies.