Neuroblastoma Mouse Model
作者： Hiroshi Iwakura , Takashi Akamizu
DOI: 10.1007/978-94-007-2418-1_4
关键词: Neuroblastoma 、 Molecular pathogenesis 、 Transgene 、 Intensive therapy 、 Neuroscience 、 Carcinogenesis 、 Childhood cancer 、 Cancer research 、 Medicine
摘要: Neuroblastoma, which arises from sympathetic neural precursors, is the most common childhood cancer. The prognosis of advanced neuroblastoma remains poor even with intensive therapy. To develop new therapeutic agents, researchers have explored molecular pathogenesis neuroblastoma. Animal models are an indispensable tool for research. This chapter reviews mouse models, ranging classic xenograft to recently-developed genetically-engineered discusses insight obtained these models.
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