Associations of allelic differences at the A-I/C-III/A-IV gene cluster with carotid artery intima-media thickness and plasma lipid transport in hypercholesterolemic-hypertriglyceridemic humans.

摘要: Individuals with elevated levels of plasma cholesterol and triglyceride may be at higher risk for coronary artery disease than those isolated elevations either or triglyceride. Sequence variation in the A-I/C-III/A-IV gene cluster has been implicated etiology some disorders associated premature atherosclerosis and/or hypertriglyceridemias without cholesterol. This led to hypothesis that allelic this locus alters lipid transport affects susceptibility atherosclerosis. The study population, from Atherosclerosis Risk Communities (ARIC) Study, consisted 50 normolipidemic individuals, 48 subjects cholesterol, 47 triglyceride, 123 both who were used evaluate associations between an Xmn I polymorphic site 2.5 kilobase pairs (kbp) upstream structural apolipoprotein (apo) A-I, intimal-medial thickening extracranial carotid arteries, several factors. relative allele frequencies 8.3-kbp 6.6-kbp .86 .14, respectively, entire population did not differ among phenotypes. In group possessing exhibited a greater thickness (P = .034) apoA-I, high-density lipoprotein (HDL) HDL3 < .02) homozygous allele. contrast, displayed lower mean ratios apolipoproteins C-II C-III, A-IV E .05) ratio C-III triglyceride-rich lipoproteins .026). near genes encoding therefore identify hypercholesterolemic-hypertriglyceridemic persons are others same phenotype.