Genetic Variation of Apolipoproteins in North Indians
作者： Puneet Pal Singh , Monica Singh , Sarabjit S. Mastana
关键词: Genetic variation 、 Population 、 Locus (genetics) 、 Genetic distance 、 Allele 、 Genetics 、 Genetic marker 、 Apolipoprotein E 、 Allele frequency 、 Biology
摘要: Genetic variation at three apolipoprotein loci (APOA4, APOH, and APOE) has been examined in nine endogamous populations of Punjab, North India. The overall pattern allele frequency different is compatible with that European populations, but observed microvariation differentiates the according to their position Indian caste structure. most common APOA4 locus was APOA4*1 a narrow range (89%-92%). APOH*2 highest these (0.852-0.914). APOE*E4 relatively low (6%-10%) compared its many populations. anthropological usage polymorphisms evaluated using multivariate analyses. distance analysis principal correspondence showed are closest Europeans, followed by Chinese African Overall, this study highlights usefulness apolipoproteins as genetic markers for clinical, population, studies.
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