GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries
作者： Brandon S.J. Davies , Anne P. Beigneux , Richard H. Barnes , Yiping Tu , Peter Gin
DOI: 10.1016/J.CMET.2010.04.016
关键词:
摘要: The lipolytic processing of triglyceride-rich lipoproteins by lipoprotein lipase (LPL) is the central event in plasma lipid metabolism, providing lipids for storage adipose tissue and fuel vital organs such as heart. LPL synthesized secreted myocytes adipocytes, but then finds its way into lumen capillaries, where it hydrolyzes triglycerides. mechanism which reaches capillaries has remained an unresolved problem metabolism. Here, we show that GPIHBP1 responsible transport capillaries. In Gpihbp1-deficient mice, mislocalized to interstitial spaces surrounding adipocytes. Also, located at basolateral surface capillary endothelial cells actively transports across cells. Our experiments define function triglyceride metabolism provide a
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