Association between Hypercoagulability and Decreased Survival in Horses with Ischemic or Inflammatory Gastrointestinal Disease

摘要: Background: Coagulopathies are common in horses with ischemic or inflammatory gastrointestinal (GI) disturbances. There is indirect evidence suggesting that early stages of these diseases characterized by hypercoagulability (HC). Hypothesis/Objectives: HC, assessed via thromboelastography (TEG), GI diseases. The degree HC correlated nonsurvival and thrombotic complications. Animals: Thirty client-owned disease, 30 nonischemic healthy (control group). Methods: Prospective, observational clinical study. TEG profiles disease were obtained on admission 48 hours after admission, compared from controls. Prothrombin time (PT), activated partial thromboplastin (aPTT), antithrombin activity (AT), D-Dimer concentrations also determined disease. Results: Horses had shorter R times (14.8 ± 8.3 versus 22.8 12 minute; P= .011). However, changes subtle did not resembled those animals humans presumed to be hypercoagulable. Although conventional coagulation testing supported the presence (decreased AT increased concentrations), abnormalities rarely found same methods statistically related. Conclusions Clinical Importance: but techniques for diagnoses require refinement.