Relaxin Modulates Collagen Type I and Matrix Metalloproteinase-1 Expression by Human Periodontal Ligament Cells
作者： Machi Takano , Masaru Yamaguchi , Ryo Nakajima , Tadashi Kojima , Kazutaka Kasai
DOI: 10.1016/S1349-0079(08)80011-4
关键词:
摘要: Abstract Relaxin, a member of the insulin/relaxin family structurally related hormones, binds to receptors that are part leucine-rich repeat G-protein receptor (LGR7 and LGR8). Furthermore, it influences many other physiologic processes, such as collagen turnover, angiogenesis, antifibrosis; therefore, relaxin may also affect orthodontic tooth movement through alterations periodontal ligament (PDL), although little is known regarding relationship between human PDL (hPDL) cells. In present study, we investigated whether hPDL cells contain LGR7 LGR8, in order evaluate effects on expression typeI (Col-I) typeIII (Col-III), well matrix metalloproteinase 1 (MMP-1) vitro . The expressions LGR8 were detected using immunocytochemistry RT-PCR methods. Further, treated with decreased release gene Col-I increased MMP-1 dose-dependent manner (p
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