Effects of topical application of lipopolysaccharide and proteases on hepatic injury induced by high-cholesterol diet in rats.

摘要: Yamamoto T, Tomofuji Tamaki N, Ekuni D, Azuma Sanbe T. Effects of topical application lipopolysaccharide and proteases on hepatic injury induced by high-cholesterol diet in rats. J Periodont Res 2009; doi: 10.1111/j.1600-0765.2009.01212.x. © 2009 The Authors. Journal compilation Blackwell Munksgaard Background Objective:  Topical to the gingival sulcus not only periodontal inflammation but also detectable liver changes rats fed a normal diet. However, these were sufficient induce pathological consequences. purpose present study was investigate whether inflammation-induced change would have more dramatic consequences compared with effect alone. Material Methods:  Twenty-four male Wistar divided into four groups. During an 8 week experimental period, two groups other containing 1% cholesterol (w/w) 0.5% cholic acid (w/w). Four weeks prior end one each dietary received daily sulcus, while treated pyrogen-free water. Results:  In without proteases, serum level hexanoyl-lysine, scores steatosis inflammation, concentration 8-hydroxydeoxyguanosine higher than those diet, without. Conclusion:  rat model, augmented steatosis, oxidative damage liver.