Concurrent targeting of eicosanoid receptor 1/eicosanoid receptor 4 receptors and COX-2 induces synergistic apoptosis in Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus associated non-Hodgkin lymphoma cell lines.
作者： Arun George Paul , Bala Chandran , Neelam Sharma-Walia
DOI: 10.1016/J.TRSL.2013.02.008
关键词:
摘要: The effective antitumorigenic potential of nonsteroidal anti-inflammatory drugs (NSAIDs) and eicosonoid (EP; EP1-4) receptor antagonists prompted us to test their efficacy in Kaposi's sarcoma-associated herpesvirus (KSHV) Epstein-Barr virus (EBV) related lymphomas. Our study demonstrated that (1) EP1-4 protein levels vary among the various non-Hodgkin's lymphoma (NHL) cell lines tested (BCBL-1:KSHV+/EBV-;BC-3: KSHV+/EBV-; Akata/EBV+: KSHV-/EBV+; JSC-1 cells: KSHV+/EBV + cells); (2) 5.0 μM EP1 antagonist (SC-51322) had a significant antiproliferative effect on BCBL-1, BC-3, Akata/EBV+, cells; (3) 50.0 EP2 (AH6809) was required induce (4) EP4 (GW 627368X) (5) COX-2 selective inhibitor celecoxib (5.0 μM) effects (6) combination 1.0 each celecoxib, SC-51322 GW 627368X could potentiate proapoptotic properties or vice-versa. Overall, our studies identified synergistic NSAIDs EP blockers KSHV EBV B malignancies.
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