TP53 and mutations in human cancer.

摘要: TP53 is the most frequently mutated gene in human cancer, with a predominance of missense mutations scattered over 200 codons. In many cancers, specific mutation patterns can be identified, which are shaped by site-specific mutagenesis and biological selection. tobacco-related cancers (lung, head neck), organ-specific observed, compatible ones experimentally induced tobacco carcinogens. several other such as squamous cell carcinoma oesophagus or hepatocellular (HCC), show geographic variations between regions high low incidence, suggesting role for region-specific risk factors. HCC from high-incidence showing also prevalence Ser-249 one striking examples mutagen fingerprint. All assessments useful to generate clues on mutagenic mechanisms involved cancer. Moreover, it has been shown that DNA retrieved plasma successfully used detection mutations, gives hope earlier more accurate cancers.