Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
作者： Gerd P Pfeifer , Mikhail F Denissenko , Magali Olivier , Natalia Tretyakova , Stephen S Hecht
关键词: Cancer research 、 Carcinogen 、 Tobacco smoke 、 Lung cancer 、 DNA damage 、 Biology 、 Mutation 、 CpG site 、 Transversion 、 Gene
摘要: It is estimated that cigarette smoking kills over 1 000 000 people each year by causing lung cancer as well as many other neoplasmas. p53 mutations are frequent in tobacco-related …
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Harry Rubin, Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates Carcinogenesis. ,vol. 22, pp. 1903- 1930 ,(2001) , 10.1093/CARCIN/22.12.1903
Abraham Rivenson, Shantu Amin, Bogdan Prokopczyk, Dietrich Hoffmann, Stephen S. Hecht, Induction of Lung and Exocrine Pancreas Tumors in F344 Rats by Tobacco-specific and Areca-derived N-Nitrosamines Cancer Research. ,vol. 48, pp. 6912- 6917 ,(1988)
M. F. Denissenko, J. X. Chen, M.-s. Tang, G. P. Pfeifer, Cytosine methylation determines hot spots of DNA damage in the human P53 gene. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 3893- 3898 ,(1997) , 10.1073/PNAS.94.8.3893
Peri Noori, Sai-Mei Hou, Mutational spectrum induced by acetaldehyde in the HPRT gene of human T lymphocytes resembles that in the p53 gene of esophageal cancers. Carcinogenesis. ,vol. 22, pp. 1825- 1830 ,(2001) , 10.1093/CARCIN/22.11.1825
Melissa West, Moon-shong Tang, James X. Chen, Yi Zheng, Carcinogens Preferentially Bind at Methylated CpG in the p53 Mutational Hot Spots Cancer Research. ,vol. 58, pp. 2070- 2075 ,(1998)
Pierre Hainaut, Magali Olivier, Gerd P Pfeifer, TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database. Mutagenesis. ,vol. 16, pp. 551- 553 ,(2001) , 10.1093/MUTAGE/16.6.551
Nicholas E. Geacintov, Is intercalation a critical factor in the covalent binding of mutagenic and tumorigenic polycyclic aromatic diol epoxides to DNA Carcinogenesis. ,vol. 7, pp. 759- 766 ,(1986) , 10.1093/CARCIN/7.5.759
T. Paschke, Analysis of different versions of the IARC p53 database with respect to G-->T transversion mutation frequencies and mutation hotspots in lung cancer of smokers and non-smokers. Mutagenesis. ,vol. 15, pp. 457- 458 ,(2000) , 10.1093/MUTAGE/15.6.457
Janice R. Thornton-Manning, Alan R. Dahl, William E. Bechtold, William C. Griffith, Rogene F. Hederson, Disposition of butadiene monoepoxide and butadiene diepoxide in various tissues of rats and mice following a low-level inhalation exposure to 1,3-butadiene Carcinogenesis. ,vol. 16, pp. 1723- 1731 ,(1995) , 10.1093/CARCIN/16.8.1723
B Singer, D Grunberger, B Singer, D Grunberger, Reactions of Directly Acting Agents with Nucleic Acids Molecular Biology of Mutagens and Carcinogens. pp. 45- 96 ,(1983) , 10.1007/978-1-4613-3772-0_4