Frequent Nitric Oxide Synthase-2 Expression in Human Colon Adenomas: Implication for Tumor Angiogenesis and Colon Cancer Progression

摘要: Abstract An increased expression of nitric oxide synthase (NOS) has been observed in human colon carcinoma cell lines as well gynecological, breast, and central nervous system tumors. This observation suggests a pathobiological role tumor-associated NO production. Hence, we investigated NOS cancer respect to tumor staging, NOS-expressing type(s), nitrotyrosine formation, inflammation, vascular endothelial growth factor expression. Ca2+-dependent activity was found normal tumors but significantly decreased adenomas (P