Chemotherapeutic induction of long-term remission in metastatic medulloblastoma.
作者： Eugen Leo , Paul G. Schlegel , Albrecht Lindemann
关键词:
摘要: The treatment of extraneural metastatic medulloblastoma is mainly a domain chemotherapy. Although previous results were promising, the overall poor prognosis, high relapse rates and still unknown ideal combination chemotherapeutic agents leave many questions open. In this study, effectiveness previouslyused for reviewed, complexityof emerging new strategies including high-dose chemotherapy with bone marrow peripheral blood stem-cell transplantation are discussed.Furthermore, we describe case bone-metastasized recurrent longest remission ever reported (120 months) after regimens containing doxorubicine, vincristine, cyclophosphamide (ACO-protocol) [1, 2] methotrexate. When infiltration occurred, second chemotherapeutically induced complete was achieved. High-dose-chemotherapy autologous used as consolidating regimen. Complete has persisted over 15 months now.
springer.com
sci-hub.se 参考文章(27)
W Brugger, J Frisch, G Schulz, K Pressler, R Mertelsmann, L Kanz, Sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following standard-dose combination chemotherapy with etoposide, ifosfamide, and cisplatin. Journal of Clinical Oncology. ,vol. 10, pp. 1452- 1459 ,(1992) , 10.1200/JCO.1992.10.9.1452
H S Friedman, J P Krischer, P Burger, W J Oakes, B Hockenberger, M D Weiner, J M Falletta, D Norris, A H Ragab, D H Mahoney, Treatment of children with progressive or recurrent brain tumors with carboplatin or iproplatin: a Pediatric Oncology Group randomized phase II study. Journal of Clinical Oncology. ,vol. 10, pp. 249- 256 ,(1992) , 10.1200/JCO.1992.10.2.249
Mitsusuke Miyagami, Kiminori Satoh, Takashi Tsubokawa, A long surviving case of recurrent medulloblastoma displaying effectiveness of ACNU/vincristine chemotherapy Journal of Neuro-oncology. ,vol. 18, pp. 41- 47 ,(1994) , 10.1007/BF01324602
M. P. Aragonés, R. Magallón, C. Piqueras, L. Ley, J. Vaquero, G. Bravo, Medulloblastoma in adulthood: prognostic factors influencing survival and recurrence. Acta Neurochirurgica. ,vol. 127, pp. 65- 68 ,(1994) , 10.1007/BF01808549
Mark G. Belza, Sarah S. Donaldson, Gary K. Steinberg, Richard S. Cox, Philip H. Cogen, Medulloblastoma: freedom from relapse longer than 8 years--a therapeutic cure? Journal of Neurosurgery. ,vol. 75, pp. 575- 582 ,(1991) , 10.3171/JNS.1991.75.4.0575
Paul H. Cottu, Sylvie Giacchetti, Laurent Mignot, Bernard Epardeau, Bernard Visot, Jean M. Extra, Marc Espie, Michel Marty, High dose chemotherapy with stem-cell transplantation in a metastatic medulloblastoma in an adult: a case report and review of the literature. Journal of Neuro-oncology. ,vol. 18, pp. 19- 23 ,(1994) , 10.1007/BF01324599
Richard L. Heideman, Roger J. Packer, Gregory H. Reaman, Jeffrey C. Allen, Beverly Lange, Marc E. Horowitz, Seth M. Steinberg, Andrea Gillespie, Edward H. Kovnar, Frank M. Balis, David G. Poplack, A phase II evaluation of thiotepa in pediatric central nervous system malignancies Cancer. ,vol. 72, pp. 271- 275 ,(1993) , 10.1002/1097-0142(19930701)72:1<271::AID-CNCR2820720147>3.0.CO;2-K
C. C. Bailey, A. Gnekow, S. Wellek, M. Jones, C. Round, J. Brown, A. Phillips, M. K. Neidhardt, Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II. Medical and Pediatric Oncology. ,vol. 25, pp. 166- 178 ,(1995) , 10.1002/MPO.2950250303
R. B. LIVINGSTON, Small-Cell Carcinoma of the Lung: Combined Chemotherapy and Radiation Annals of Internal Medicine. ,vol. 88, pp. 194- 199 ,(1978) , 10.7326/0003-4819-88-2-194
JoelH. Lundberg, DavidE. Weissman, PeterA. Beatty, RobertC. Ash, Treatment of recurrent metastatic medulloblastoma with intensive chemotherapy and allogeneic bone marrow transplantation. Journal of Neuro-oncology. ,vol. 13, pp. 151- 155 ,(1992) , 10.1007/BF00172764