Suppression of uPAR Retards Radiation-Induced Invasion and Migration Mediated by Integrin β1/FAK Signaling in Medulloblastoma
作者： Arun Kumar Nalla , Swapna Asuthkar , Praveen Bhoopathi , Meena Gujrati , Dzung H. Dinh
DOI: 10.1371/JOURNAL.PONE.0013006
关键词:
摘要: Background Despite effective radiotherapy for the initial stages of cancer, several studies have reported recurrence various cancers, including medulloblastoma. Here, we attempt to capitalize on radiation-induced aggressive behavior medulloblastoma cells by comparing extracellular protease activity and expression pattern molecules, known be involved in cell adhesion, migration invasion, between non-irradiated irradiated cells.
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Erito Mochiki, Yoshitaka Toyomasu, Takayuki Asao, Tetsuro Ohno, Hiroyuki Kuwano, Hiroyuki Ando, Kyoichi Ogata, Mitsuhiro Yanai, Ryuusuke Aihara, Factors correlated with early and late recurrence after curative gastrectomy for gastric cancer Hepato-gastroenterology. ,vol. 56, pp. 1760- 1764 ,(2009)
Eugen Leo, Paul G. Schlegel, Albrecht Lindemann, Chemotherapeutic induction of long-term remission in metastatic medulloblastoma. Journal of Neuro-oncology. ,vol. 32, pp. 149- 154 ,(1997) , 10.1023/A:1005721510659
Li-Min Sun, Shyh-An Yeh, Chong-Jong Wang, Eng-Yen Huang, Hui-Chun Chen, Hsuan-Chih Hsu, Steve P. Lee, Postoperative radiation therapy for medulloblastoma--high recurrence rate in the subfrontal region. Journal of Neuro-oncology. ,vol. 58, pp. 77- 85 ,(2002) , 10.1023/A:1015865614640
Richard O. Hynes, Integrins: Bidirectional, Allosteric Signaling Machines Cell. ,vol. 110, pp. 673- 687 ,(2002) , 10.1016/S0092-8674(02)00971-6
Benjamin Geiger, Alexander Bershadsky, Roumen Pankov, Kenneth M. Yamada, Transmembrane crosstalk between the extracellular matrix and the cytoskeleton Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 793- 805 ,(2001) , 10.1038/35099066
Stephanie L. Gupton, Clare M. Waterman-Storer, Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. Cell. ,vol. 125, pp. 1361- 1374 ,(2006) , 10.1016/J.CELL.2006.05.029
Encarnaci�n Lozano, Martha Betson, Vania M.M. Braga, Tumor progression: Small GTPases and loss of cell-cell adhesion BioEssays. ,vol. 25, pp. 452- 463 ,(2003) , 10.1002/BIES.10262
Marcelina E. Janik, Anna Lityńska, Pierre Vereecken, Cell migration-the role of integrin glycosylation. Biochimica et Biophysica Acta. ,vol. 1800, pp. 545- 555 ,(2010) , 10.1016/J.BBAGEN.2010.03.013
Deborah A Kuban, Howard D Thames, Larry B Levy, Eric M Horwitz, Patrick A Kupelian, Alvaro A Martinez, Jeff M Michalski, Thomas M Pisansky, Howard M Sandler, William U Shipley, Michael J Zelefsky, Anthony L Zietman, Long-term multi-institutional analysis of stage T1–T2 prostate cancer treated with radiotherapy in the PSA era ☆ International Journal of Radiation Oncology Biology Physics. ,vol. 57, pp. 915- 928 ,(2003) , 10.1016/S0360-3016(03)00632-1
Allison L. Berrier, Kenneth M. Yamada, Cell–matrix adhesion Journal of Cellular Physiology. ,vol. 213, pp. 565- 573 ,(2007) , 10.1002/JCP.21237