Apoptosis Induced by Knockdown of uPAR and MMP-9 is Mediated by Inactivation of EGFR/STAT3 Signaling in Medulloblastoma
作者： Ramaprasada Rao Kotipatruni , Arun Kumar Nalla , Swapna Asuthkar , Christopher S. Gondi , Dzung H. Dinh
DOI: 10.1371/JOURNAL.PONE.0044798
关键词:
摘要: Background Medulloblastoma is a highly invasive cancer of central nervous system diagnosed mainly in children. Matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator receptor (uPAR) are over expressed several cancers well established for their roles tumor progression. The present study aimed to determine the consequences targeting these molecules on medulloblastoma
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