Tissue Microarray Analysis of Signal Transducers and Activators of Transcription 3 (Stat3) and Phospho-Stat3 (Tyr705) in Node-negative Breast Cancer Shows Nuclear Localization Is Associated with a Better Prognosis

摘要: Purpose: Although a high frequency of tumors contain constitutively activated signal transducers and activators transcription 3 (Stat3), its relationship to breast cancer patient survival has not been determined in large retrospective study node-negative tumors. To further elucidate the role Stat3 cancers, expression patterns Phospho-tyrosine residue 705 (Tyr705) were correlated with outcome clinicopathological parameters cohort Experimental Design: Immunohistochemical analysis Phospho-Stat3 was performed on tissue microarray 346 specimens. These results overall other data. Results : Positive cytoplasmic seen 69.2% tumors, positive 19.6% Neither showed significant association or clinical parameters. However, 23.1% had nuclear expression, those patients significantly improved short-term ( P = 0.0332) at 5 years follow-up. Upon 43.5% both 5-year 0.0054) long-term 20-year 0.0376) analysis. Additionally, is an independent prognostic marker better by multivariate analyses that included variables grade, Ki-67, estrogen receptor staining, progesterone Her2 age, tumor size. Conclusions: findings support for overexpression provide initial evidence may be markers.