DR-07TARGETING EGFR-VIII WITH DICHLOROACETATE IN TEMOZOLOMIDE RESISTANT GLIOBLASTOMA MODELS
K. K. Velpula , S. Asuthkar , J. D. Lathia , A. J. Tsung
Neuro-oncology 16
2014
Metabolic targeting and antagonism of the EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma models
KK Velpula , MR Guda , K Sahu , J Tuszynski
European Journal of Cancer 61
2016
Glucose transport: meeting the metabolic demands of cancer, and applications in glioblastoma treatment.
Swapna Asuthkar , Andrew J Tsung , Kiran K Velpula , Maheedhara R Guda
American Journal of Cancer Research 6 ( 8) 1599 -1608
49
2016
OTX2 expression contributes to proliferation and progression in Myc-amplified medulloblastoma.
Swapna Asuthkar , Andrew J. Tsung , Kiran Kumar Velpula , Maheedhara R. Guda
American Journal of Cancer Research 7 ( 3) 647 -656
10
2017
B7-H3 role in the immune landscape of cancer.
Swapna Asuthkar , Andrew J Tsung , Kiran K Velpula , Maheedhara R Guda
American journal of clinical and experimental immunology 6 ( 4) 66 -75
156
2017
Targeting PDK4 inhibits breast cancer metabolism.
Swapna Asuthkar , Andrew J Tsung , Kiran K Velpula , Kiran K Velpula
American Journal of Cancer Research 8 ( 9) 1725 -1738
25
2018
Therapeutic targeting of immune checkpoints with small molecule inhibitors.
Swapna Asuthkar , Rajeev Vibhakar , Andrew J Tsung , Kiran K Velpula
American Journal of Translational Research 11 ( 2) 529 -541
6
2019
Pleiotropic role of macrophage migration inhibitory factor in cancer.
Swapna Asuthkar , Andrew J Tsung , Kiran K Velpula , Maheedhara R Guda
American Journal of Cancer Research 9 ( 12) 2760 -2773
9
2019
Testosterone is a Highly Potent and Specific Agonist of TRPM8
Zahir Hussain , Lusine Demirkhanyan , Swapna Asuthkar , Eleonora Zakharian
Biophysical Journal 110 ( 3) 613a
2016
Ubiquitin-Mediated TRPM8 Protein Degradation in the Pathogenesis of Prostate Cancer
Swapna Asuthkar , Alejandro Cohen , Lusine Demirkhanyan , Eleonora Zakharian
Biophysical Journal 110 ( 3) 613a
2016
TRPM3 Exhibits Slight Temperature Sensitivity in the Planar Lipid Bilayer System and Requires the Presence of PIP2
Lusine Demirkhanyan , Kunitoshi Uchida , Swapna Asuthkar , Alejandro Cohen
Biophysical Journal 110 ( 3) 612a
2016
Hand1 overexpression inhibits medulloblastoma metastasis.
Swapna Asuthkar , Maheedhara R. Guda , Sarah E. Martin , Reuben Antony
Biochemical and Biophysical Research Communications 477 ( 2) 215 -221
2
2016
Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity
Swapna Asuthkar , Kiran Kumar Velpula , Chandramu Chetty , Bharathi Gorantla
Oncotarget 3 ( 11) 1439 -1454
112
2012
The Plasma Membrane TRPM8 Plays a Protective Role against Prostate Cancer Progression; Trpm8 Gene as a Downstream Target of P53 Tumor-Suppressor
Swapna Asuthkar , Kiran Kumar Velpula , Pia Elustondo , Eleonora Zakharian
Biophysical Journal 108 ( 2)
2015
Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma
Kiran K Velpula , Maheedhara R Guda , Kamlesh Sahu , Jack Tuszynski
Oncotarget 8 ( 22) 35639 -35655
16
2017
The TRPM8 Protein Is a Testosterone Receptor I. BIOCHEMICAL EVIDENCE FOR DIRECT TRPM8-TESTOSTERONE INTERACTIONS
Swapna Asuthkar , Pia A. Elustondo , Lusine Demirkhanyan , Xiaohui Sun
Journal of Biological Chemistry 290 ( 5) 2659 -2669
80
2015
The TRPM8 protein is a testosterone receptor: II. Functional evidence for an ionotropic effect of testosterone on TRPM8.
Swapna Asuthkar , Lusine Demirkhanyan , Xiaohui Sun , Pia A. Elustondo
Journal of Biological Chemistry 290 ( 5) 2670 -2688
64
2015
High-throughput proteome analysis reveals targeted TRPM8 degradation in prostate cancer
Swapna Asuthkar , Lusine Demirkhanyan , Samuel Robert Mueting , Alejandro Cohen
Oncotarget 8 ( 8) 12877 -12890
19
2017
Cancer stem cell molecular reprogramming of the Warburg effect in glioblastomas: a new target gleaned from an old concept
Carlen A Yuen , Swapna Asuthkar , Maheedhara R Guda , Andrew J Tsung
CNS oncology 5 ( 2) 101 -108
65
2016
Nuclear Translocation of Hand-1 Acts as a Molecular Switch to Regulate Vascular Radiosensitivity in Medulloblastoma Tumors: The Protein uPAR Is a Cytoplasmic Sequestration Factor for Hand-1
Swapna Asuthkar , Venkateswara Rao Gogineni , Jasti S. Rao , Kiran Kumar Velpula
Molecular Cancer Therapeutics 13 ( 5) 1309 -1322
3
2014