B7-H3 role in the immune landscape of cancer.

摘要: The field of immunotherapy is a continually expanding niche in cancer biology research. In the last two decades, there has been significant progress identifying better targets and creating more specific agents for therapy field. B7-H3 (CD276) an immune checkpoint from B7 family molecules, many whom interact with known markers including CTLA4, PD-1, CD28. This exciting molecule that overexpressed cancers, although receptor not characterized. Initially, was thought to co-stimulate response, but recent studies have shown it co-inhibitory role on T-cells, contributing tumor cell evasion. Therefore, its overexpression linked poor prognosis human patients invasive metastatic potential tumors vitro models. Moreover, evidence influences progression beyond regulatory roles. this review, we aim characterize roles different relationship other checkpoints, non-immunological function progression. Targeting treatment can reduce proliferation, progression, metastasis, which may ultimately lead improved therapeutic options clinical outcomes.