Torque teno mini virus infection and multiple sclerosis.
作者： Majid Komijani , Majid Bouzari , Masoud Etemadifar , Hamid Zarkesh-Esfahani , Nima Shaykh-Baygloo
DOI: 10.3109/00207454.2011.569039
关键词:
摘要: ABSTRACTMultiple sclerosis (MS) is a disease of young adults which characterized by autoimmune demyelination the central nervous system. Interaction genetics and environmental factors are required to cause MS. Among proposed for MS, viral infections thought play role in pathogenesis disease. Torque teno mini virus (TTMV), has recently been shown infect humans, member circoviridae, circular DNA with 2,860 nucleotides. Since there few data about pathogenicity this virus, study sought investigate presence TTMV sera from MS patients healthy individuals. We studied 149 serum samples 150 Serum was extracted using phenol-chloroform subjected nested polymerase chain reaction. TTMV-DNA detected 24 (16%) blood donors 21 (14.1%) patients, where difference did not reach significance ...
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