Drug-induced agranulocytosis. Peripheral destruction of polymorphonuclear leukocytes and their marrow precursors.

摘要: Drug-induced agranulocytosis is a highly individualized and unexpected reaction to specific drugs. It may be due immunogenic or cytotoxic factors. Most instances are produced by poorly understood immune response Others associated with direct suppression of marrow committed stem cells the action offending drug its toxic metabolic end products. The early appearance polymorphonuclear neutrophil (PMN) antibodies offer an warning sensitized patients. Antibodies, if present, disappear shortly after discontinued. Agranulocytosis, drug, characterized morphologic aplasia more likely occur affected host has concomitant defect in cellular proliferation. Accumulation products such as arene oxides deficient microsomal system required dispose this material.