Oxidation sensitivity may be a useful tool for the detection of the hematotoxic potential of newly developed molecules: application to antipsychotic drugs.
作者： Jean-François Liégeois , Jacques Bruhwyler , Christine Petit , Jacques Damas , Jacques Delarge
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摘要: Abstract Some antipsychotic agents have been found to produce agranulocytosis and aplastic anemia. The oxidation phenomena and/or the formation of free radicals has suggested be causally related various hematological disorders, e.g., agranulocytosis. Using five experimental conditions, we tested oxidative potential compounds with without a history side effects, A statistical analysis was undertaken for each condition multivariate combining all results performed. Two peroxidase-induced radical models did not successfully discriminate between drugs causing hematologic problems (
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