Are typical human serum BPA concentrations measurable and sufficient to be estrogenic in the general population?

摘要: Mammalian estrogen receptors modulate many physiological processes. Chemicals with structural features similar to estrogens can interact produce biological effects those caused by endogenous in the body. Bisphenol A (BPA) is a analogue of that binds receptors. Exposure BPA humans virtually ubiquitous industrialized societies, but rapidly detoxified metabolism and does not accumulate Whether or serum concentrations are sufficiently high disrupt normal estrogen-related biology subject intense political scientific debate. Here we show convergence robust methods for measuring calculating from 93 published studies more than 30,000 individuals 19 countries across all life stages. Typical orders magnitude lower levels measurable modern analytical below required occupy 0.0009% Type II Estrogen Binding Sites, GPR30, ERα ERβ Occupancies would be higher, ⩽0.04%, highest affinity receptor, ERRγ. Our results limited no potential estrogenicity humans, question reports human serum.