Pregnancy-induced hypertension--a particular pathogenic model. Similarities with other forms of arterial hypertension.

摘要: Hypertension is in 85 to 90% of cases unknown etiology, spite efforts undertaken by modern medicine elucidate it. Numerous experimental studies were conducted order explain the pathogeny this disease. Recent observations revealed that during therapy with anti-VEGF medication,used treating different forms cancer, hypertension and proteinuria occur, at kidney level endothelial injuries appear similar pregnancy-related hypertension. Antiangiogenic factors, such as sFlt-1, are produced pregnancy-induced hypertension, especially preeclampsia. They block circulating VEGF. Consequently, proteinuria, sometimes oedema occur together Renal glomerular endotheliosis type. It appreciated one can draw a parallel between these pathologic situations, ablative treatment antiangiogenic medication (anti-VEGF) preeclampsia, respectively. Since angiogenic factors have an important role, we analyse their implication other types myocardial infarction, dysfunction course CKD. The main pathogenic mechanism causes disease placental ischaemia. This followed release pressor substances involved both generalised characterizes disease, prototype caused renal ischaemia artery stenosis. Both stenosis factor pathogeny, organ production consecutive substances. ischaemic intervene its characterisation becomes importance present. Thus, pregnancy represent real model reflected non-pregnancy paper presents particularities well parallelism determined or produce ablation factors.