The chemotherapy of rodent malaria XXXIII. The activity of chloroquine and related blood schizontocides and of some analogues in drug-induced pigment clumping.
作者： D. C. Warhurst , S. Gould
DOI: 10.1080/00034983.1982.11687540
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摘要: The activity of some chloroquine, mepacrine and amodiaquine analogues in inducing autophagic vacuole formation (pigment clumping) vitro erythrocytic stages Plasmodium berghei was examined. Modifications the quinoline or acridine nucleus have more influence than side chain modifications (other replacement a nitrogen atom) on clumping activity. aromatic atom is vitally important drug-receptor interaction, severe spatial restrictions are imposed here. It probable that quinine-like drugs interact with same receptor fundamentally different way.
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