Metastasis-associated colon cancer-1 is a novel prognostic marker for cervical cancer.
作者： Lan Guo , Wanggui Lu , Xuan Zhang , Dixian Luo , Hongwen Zhang
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摘要: Aims: To investigate metastasis associated in colon cancer 1 (MACC1) expression cervical cancer. Methods: One hundred and four paraffin-embedded specimens were immunohistochemically analyzed for MACC1 expression. The of 8 pairs adjacent normal tissues detected by Real-time PCR. Results: was upregulated compared with tissues. Patients higher had shorter overall survival time, whereas those lower ASAP1 survived longer (P = 0.029). Moreover, high correlated FIGO stage 0.039) lymph nodes 0.003) this disease. Multivariate analysis revealed that an independent prognostic factor 0.043) the patients. Conclusion: Our study suggests may contribute to tumor development progression cancer, could be a useful marker prognosis
参考文章(18)
Ahmedin Jemal, Freddie Bray, David Forman, Meg O'Brien, Jacques Ferlay, Melissa Center, D. Maxwell Parkin, Cancer burden in Africa and opportunities for prevention. Cancer. ,vol. 118, pp. 4372- 4384 ,(2012) , 10.1002/CNCR.27410
Katarzyna Kokoszyńska, Jacek Kryński, Leszek Rychlewski, Lucjan S Wyrwicz, Unexpected domain composition of MACC1 links MET signaling and apoptosis. Acta Biochimica Polonica. ,vol. 56, pp. 317- 323 ,(2009) , 10.18388/ABP.2009_2464
Yuji Toiyama, Susumu Saigusa, Yasuhiko Mohri, Junichiro Hiro, Yoshinaga Okugawa, Mikio Kawamura, Keiichi Uchida, Masato Kusunoki, Yasuhiro Inoue, Koji Tanaka, Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy. Anticancer Research. ,vol. 32, pp. 1527- 1531 ,(2012)
Franziska Arlt, Ulrike Stein, Colon cancer metastasis: MACC1 and Met as metastatic pacemakers The International Journal of Biochemistry & Cell Biology. ,vol. 41, pp. 2356- 2359 ,(2009) , 10.1016/J.BIOCEL.2009.08.001
Ulrike Stein, Janice Smith, Wolfgang Walther, Franziska Arlt, MACC1 controls Met: What a difference an Sp1 site makes Cell Cycle. ,vol. 8, pp. 2467- 2469 ,(2009) , 10.4161/CC.8.15.9018
Ulrich Nitsche, Robert Rosenberg, Alexander Balmert, Tibor Schuster, Julia Slotta-Huspenina, Pia Herrmann, Franz G. Bader, Helmut Friess, Peter M. Schlag, Ulrike Stein, Klaus-Peter Janssen, Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer. Annals of Surgery. ,vol. 256, pp. 763- 771 ,(2012) , 10.1097/SLA.0B013E318272DE87
Tsunehiro Oyama, Kosei Yasumoto, Hidehiko Shimokawa, Hidetaka Uramoto, Takamitsu Onitsuka, Gu Chundong, Takeshi Hanagiri, Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence The Journal of Thoracic and Cardiovascular Surgery. ,vol. 141, pp. 895- 898 ,(2011) , 10.1016/J.JTCVS.2010.09.044
Jack Cuzick, Christine Bergeron, Magnus von Knebel Doeberitz, Patti Gravitt, Jose Jeronimo, Attila T. Lorincz, Chris J.L.M. Meijer, Rengaswamy Sankaranarayanan, Peter J.F. Snijders, Anne Szarewski, New technologies and procedures for cervical cancer screening. Vaccine. ,vol. 30, ,(2012) , 10.1016/J.VACCINE.2012.05.088
GANG WANG, MU-XING KANG, WEN-JIE LU, YING CHEN, BO ZHANG, YU-LIAN WU, MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance Oncology Letters. ,vol. 4, pp. 783- 791 ,(2012) , 10.3892/OL.2012.784
Gaëlle A.V. Boulet, Caroline A.J. Horvath, Sarah Berghmans, Johannes Bogers, Human Papillomavirus in Cervical Cancer Screening: Important Role as Biomarker Cancer Epidemiology, Biomarkers & Prevention. ,vol. 17, pp. 810- 817 ,(2008) , 10.1158/1055-9965.EPI-07-2865