Effect of gold nanoparticles on radiation doses in tumor treatment: a Monte Carlo study.

摘要: Radiotherapy is an extensively used treatment for most tumor types. However, ionizing radiation does not discriminate between cancerous and normal cells surrounding the tumor, which can be considered as a dose-limiting factor. This lead to reduction of effectiveness cell eradication with this treatment. A potential solution problem loading high-Z materials prior radiotherapy induce higher toxicity in compared ones. New advances nanotechnology have introduced promising use heavy metal nanoparticles enhance The primary studies showed that gold (GNPs) unique characteristics biocompatible radiosensitizers cells. study aimed quantify dose enhancement effect its radial distribution by Monte Carlo simulations utilizing EGSnrc code water–gold phantom loaded seven different concentrations Au: 0, 7, 18, 30, 50, 75, 100 mg-Au/g-water. was irradiated two radionuclide sources, Ir-192 Cs-137, are commonly brachytherapy, all concentrations. results exhibited nanoparticle-aided (GNRT) increases efficacy low-energy photon sources accompanied high Au concentration loads up 30 Our finding conducts also detection effects short average range 650 μm outside region Au. indicate location determination highly important method.