The Rise and Fall of the Mycobacterium tuberculosis Complex
作者： Marcel A. Behr , Sébastien Gagneux
DOI: 10.1016/B978-0-12-384890-1.00024-8
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摘要: Publisher Summary This chapter explains the Mycobacterium tuberculosis Complex, genus and evolution of tuberculosis. It defines organisms which are subject consideration outlines about their role in human veterinary disease. The current understanding mycobacterium situation M. within this discussed. also describes species bovis with examples delves into results genetic studies complex inferences these findings on population biology organism. leprae is cause leprosy, organism was second to have its genome determined. situated a more ancestral position, larger genome, while derived smaller served as parental strain for BCG vaccines that represented. strong reduction purifying selection against nonsynonymous changes. When authors analyzed specific antigen regions known interact T cells, they found cell epitopes were most conserved all genomic analyzed. has reason ability disease large number hosts still unknown. concludes challenge at hand harness new data, translate it insights, use information help inform next generation TB research.
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