Silent Nucleotide Polymorphisms and a Phylogeny forMycobacterium tuberculosis

摘要: Much remains unknown of the phylogeny and evolution Mycobacterium tuberculosis, an organism that kills 2 million people annually. Using a population-based approach analyzes multiple loci around chromosome, we demonstrate neutral genetic variation in genes associated with antimicrobial drug resistance has sufficient to construct robust phylogenetic tree for M. tuberculosis. The data describe clonal population minimum four distinct tuberculosis lineages, closely related bovis. lineages are strongly geographically associated. Nucleotide substitutions proven cause distributed throughout tree, whereas nonsynonymous base unrelated have restricted distribution. structure is concordant all previously described genotypic phenotypic groupings strains provides unifying framework both epidemiologic evolutionary analysis populations.