Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center

作者: Qiuyu Li , Di Song , Fengmei Wang , Ying Tan , Feng Yu

DOI: 10.1155/2014/212597

关键词:

摘要: Objective. To assess clinicopathological characteristics of lupus nephritis patients with scanty immune deposits. Methods. The data deposits were retrospectively analyzed. Plasma ANCA and complement components detected. Results. Among 316 cases renal biopsy-proven nephritis, 40 diagnosed as There significantly higher value serum creatinine () lower hemoglobin level score cellular crescents in group compared complex group. frequency positive plasma was than that (52.5% versus 10.1%, ). As for comparisons components, there levels C1q Bb factor H ratio treatment failure (42.5% 19.20%, outcomes similar between the two groups. Conclusions. Patients had more severe kidney damage. activation alternative pathway might be involved pathogenesis disease.

参考文章(43)
Igor Y Pavlov, Julio C Delgado, Nikol De Forest, Specificity of EIA immunoassay for complement factor Bb testing. Clinical Laboratory. ,vol. 57, pp. 225- 228 ,(2011)
V D'Agati, C L Pirani, G B Appel, Renal vascular complications of systemic lupus erythematosus. Journal of The American Society of Nephrology. ,vol. 4, pp. 1499- 1515 ,(1994) , 10.1681/ASN.V481499
Matthew H. Liang, Steven A. Socher, Martin G. Larson, Peter H. Schur, Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus Arthritis & Rheumatism. ,vol. 32, pp. 1107- 1118 ,(1989) , 10.1002/ANR.1780320909
Naveed N. Masani, Louis J. Imbriano, Vivette D. D’Agati, Glen S. Markowitz, SLE and Rapidly Progressive Glomerulonephritis American Journal of Kidney Diseases. ,vol. 45, pp. 950- 955 ,(2005) , 10.1053/J.AJKD.2004.08.047
P. Sánchez-Corral, D. Bellavia, L. Amico, M. Brai, S. Rodríguez de Córdob, Molecular basis for factor H and FHL-1 deficiency in an Italian family. Immunogenetics. ,vol. 51, pp. 366- 369 ,(2000) , 10.1007/S002510050631
Feng Yu, Ying Tan, Gang Liu, Su-xia Wang, Wan-zhong Zou, Ming-hui Zhao, Clinicopathological characteristics and outcomes of patients with crescentic lupus nephritis Kidney International. ,vol. 76, pp. 307- 317 ,(2009) , 10.1038/KI.2009.136
G Nagy, M Brózik, L Varga, G Füst, M Kirschfink, E Kiss, P Gergely, Usefulness of detection of complement activation products in evaluating SLE activity. Lupus. ,vol. 9, pp. 19- 25 ,(2000) , 10.1177/096120330000900105
Howard A. Austin, Larry R. Muenz, Kathleen M. Joyce, Tatiana T. Antonovych, James E. Balow, Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome. Kidney International. ,vol. 25, pp. 689- 695 ,(1984) , 10.1038/KI.1984.75
Eduardo JM Nascimento, Ana M Silva, Marli T Cordeiro, Carlos A Brito, Laura HVG Gil, Ulisses Braga-Neto, Ernesto TA Marques, None, Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity PLoS ONE. ,vol. 4, pp. e6782- ,(2009) , 10.1371/JOURNAL.PONE.0006782