Placental inflammation and oxidative stress in the mouse model of assisted reproduction.

摘要: Higher rates of low birth weight and prematurity are observed in pregnancies generated with assisted reproduction technologies (ART). Both conditions have been associated placental inflammation oxidative stress. Since fetal levels progesterone, a major anti-inflammatory steroid, decreased murine ART, we investigated stress this model as potential mediators negative outcomes. After generating mouse by vitro fertilization (IVF) intracytoplasmic sperm injection (ICSI) evaluated the antioxidant defense network inflammatory cytokines maternal, tissues. Additionally, placentas were analyzed for total lipid levels, fibrosis, apoptosis, reactive oxygen species integrity intracellular nucleotides. Placentas from ART contained significantly less lipids, greater apoptosis degraded ICSI had lower activities superoxide dismutase (SOD), thioredoxin reductase (TrxR), xanthine oxidase (XO), catalase, glutathione-S-transferase (GST) glutathione peroxidase, (GR). Furthermore, GR, GST SOD also livers pregnancies. IVF SOD, TrxR XO only. In both IL-6 increased. These data suggest that is (IL-6), but not fibrosis or remodeling. effects markedly technique. ubiquitous, method may be critical factor outcomes such weight.