Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome

摘要: Background: Reproductive disorders and infertility are associated with the risk of obstetric complications have a negative impact on pregnancy outcome. Affected patients often require assisted reproductive technologies (ART) to conceive, advanced maternal age is further confounding factor. The challenge dissect causation, correlation confounders in determining how individually or together predispose women poor outcomes. methods: published literature, June 2015, was searched using PubMed, summarizing all evidences concerning perinatal outcome potential mechanisms that may influence Results: (endometriosis, adenomyosis, polycystic ovary syndrome uterine fibroids) unexplained share inflammatory pathways, hormonal aberrations, decidual senescence vascular abnormalities impair success through common mechanisms. Either combination alone, these results an increased preterm birth, fetal growth restriction, placental pathologies hypertensive disorders. Systemic metabolic factors acting endometrium, myometrium, cervix placenta aberrant milieu during implantation pregnancy, thus contributing genesis complications. Some features been also described placentas from ART. Conclusions: arecommoninwomenof childbearing rarely occur isolation. Inflammatory, endocrine responsible for incidence These should be recognized as 'high risk' outcomes monitored specialized follow-up. There real need development evidence-based recommendations about clinical management specific care pathways introduction prompt preventative measures.