Cervical Length and Androgens in Pregnant Women With Polycystic Ovary Syndrome: Has Metformin Any Effect?
作者： Tone Shetelig Løvvik , Solhild Stridsklev , Sven M. Carlsen , Øyvind Salvesen , Eszter Vanky
DOI: 10.1210/JC.2015-3498
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摘要: Context: Women with polycystic ovary syndrome (PCOS) have increased risk of preterm delivery. Shortening the cervix is a sign Objective: This study aimed to investigate potential effect metformin on cervical length and whether androgen levels correlate in PCOS pregnancies. Design Setting: was sub-study randomized, placebo-controlled, multicenter (The PregMet study) performed at 11 secondary or tertiary centers from 2005 2009. Participants: Two-hundred sixty-one pregnancies 245 women PCOS, age 18–42 years participated. Interventions: Participants were randomly assigned placebo first trimester Outcome Measurements: We compared groups gestational weeks 19 32. also explored correlated levels. Results: found no difference between at...
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