Effects of chronic exposure to coal in wild rodents (Ctenomys torquatus) evaluated by multiple methods and tissues

摘要: Rio Grande do Sul (RS) coal is low quality and typically obtained by strip mining. In a recent study concerning 2 years of biomonitoring in regions, we demonstrated the genotoxicity related products on blood cells native rodents, from RS, Brazil. With goal studying variations effects RS different tissues same rodent, utilized, besides single cell gel (SCG) micronucleus (MN) assay blood, histological analyses SCG bone marrow, spleen, kidney, liver lung cells, MN marrow spleen cells. addition, to identify agents that can potentially influence results, concentrations several heavy metals were analyzed livers soil, total concentration hydrocarbons soil was determined. Rodents exposed captured at two sites, Butia Candiota, RS. Reference animals Pelotas, where there no This report provides chemical biological data indicating possible association between Zn, Ni, Pb induction DNA damage (e.g. strand-breaks alkali-labile sites) determined alkaline Ctenomys torquatus. The results present indicate by-products not only induce but also other tissue mainly liver, kidney lung. Neither nor histopathological observations showed significant differences; these may be useful under circumstances higher. conclusion believe vivo biomonitored assay, our studies suggest wild such as C. torquatus are for monitoring genotoxic both methods, test.