Mild Guillain-Barré syndrome

摘要: Background The unpredictability of the early course Guillain-Barre syndrome (GBS) makes it difficult to determine which patients' conditions will worsen under observation. Most large randomized treatment trials for GBS have used an inability walk as enrollment criterion. Consequently, little is known about those patients with milder degrees affection. Objectives To approximate frequency mild persistent ability and see if there were features that predicted illness would remain mild. Setting A registry seen on wards in neurology clinic from January 1,1992, May 1, 2000, a 400-bed community teaching hospital. Patients Twelve (4.7%) 254 our case series able throughout their illness. Eight had been treated plasmapheresis or intravenous immunoglobulin; others observed without treatment. Results There was no age, sex, seasonal preponderance comparison included cases all severities. Nine 12 preceding respiratory tract infection, 10 paresthesias, 7 prominent pain, 9 ataxia. Seven who examined normal cerebrospinal fluid protein levels. It took 8 days, average, reach maximal degree weakness. One additional patient, excluded series, weakness first 3 weeks subsequently worsened relapsing more typical chronic inflammatory demyelinating polyneuropathy. Eleven demonstrated proximal, intermediate, distal conduction block, only denervation. distinguishing clinical electrophysiologic between untreated and, except affection absence substantial electromyographic changes axonal disruption, important differences these group developed severe GBS. Conclusions Cases nadir similar time disease. Treatment may be unnecessary are during second week illness, but observation until approximately eighth day seems appropriate certain does not progress. In likelihood never come attention neurologist.